September was a landmark month in Huntington's disease research: a gene therapy shows signs of slowing progression, plus new biomarkers, mechanistic insights and mental health advances. The field has come far and exciting directions lie ahead.

In an update from uniQure, they report that their experimental gene therapy, AMT-130, has the potential to slow Huntington's disease progression in key clinical study.

We're proud to announce Mustafa Mehkary as a 2025 HDBuzz Prize winner! New findings reveal that the huntingtin protein is a key player in the cell’s DNA repair crew. In HD, the crew falls apart leaving DNA damage and alarm bells ringing in its wake.